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Accueil > Offres d’emploi > Postdocs > Post-doctoral position : Magnetic molecularly imprinted polymers in organic synthesis : from standard to dynamic kinetic resolution

Post-doctoral position : Magnetic molecularly imprinted polymers in organic synthesis : from standard to dynamic kinetic resolution

par Emilie Secret - 16 juin

Offer type : one year postdoctoral position funded by Emergence Sorbonne Université
Salary range : ≥ 35.000 and < 45.000€ annual gross
Employer : Sorbonne Université
Workplace : Campus Pierre et Marie Curie, 4 place Jussieu 75005 – Paris
Skill area : polymer, nanomaterials, catalysis, chirality

Dynamic kinetic resolution (DKR) has emerged as a powerful approach for asymmetric synthesis, allowing the efficient conversion of a racemic mixture of a compound, easier to obtain, into a unique enantiomer. This significant improvement of standard kinetic resolution (KR), limited with a maximum of 50% conversion, proceeds through the selective transformation of one enantiomer by organometallic catalysis or biocatalysis and the racemization of the remaining one which can be converted in turn.

The last few years have witnessed great improvements in the field of Molecularly Imprinted Polymers (MIPs), highly cross-linked macromolecular architectures capable of selective molecular recognition. MIPs exhibit excellent binding properties with affinity and selectivity often comparable to those of antibodies. Their combination with magnetic nanoparticles (Fe2O3) has conferred them new separation properties using a magnet.

We propose here to design a new DKR system that simply combines enantiomer recognition by the magnetic MIP nanoparticles and racemization methods according to the substrate used. In other words, one enantiomer is trapped by magnetic MIP nanoparticles, the other one is racemized allowing the progressive shift of the equilibrium in the direction of formation of a single enantiomer (Scheme 1). The polymer can then release the enantiomerically enriched product. Proofs of concept have already been established for standard KR, and then in the DKR. Extension to other examples of asymmetric resolution will be considered on the basis of our initial studies.

Mission : This post allows a talented, driven and motivated scientist to develop an exciting project aimed at investigating the earliest specification events. Standing at the crossroads of several fields of chemistry and more specifically green chemistry, molecular and macromolecular chemistry, physical chemistry, organometallic chemistry, radical chemistry, this project offers a strong multidisciplinary character.

Candidates profile :
• A PhD or near to completion
• A strong background in physical chemistry
• Excellent organizational and time-management skills
• Knowledge in organic/polymer chemistry and/or magnetic nanomaterials synthesis
• Ability to communicate results clearly and succinctly
• Ability to work as a team member and to work independently

Contacts :
Nébéwia GRIFFETE, PHysichochimie des Electrolytes et des Nanosystèmes InterfaciauX (PHENIX), UMR CNRS 8234, Sorbonne Université,, 01 44 27 40 33.
Cyril OLLIVIER, Institut Parisien de Chimie Moléculaire (IPCM), UMR CNRS 8232, Sorbonne Université,, 01 44 27 38 50
Karsten HAUPT, Enzyme and cell engineering, UMR 7025 CNRS, Compiègne University of Technology, Compiègne 60205,, 03 44 23 44 55