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Accueil du site > Offres d’emploi > Stages > Stage de M2 : Synthesis of (nano)hybrid materials combining plasmonics and molecularly imprinted polymers for cancer therapy

Stage de M2 : Synthesis of (nano)hybrid materials combining plasmonics and molecularly imprinted polymers for cancer therapy

par Emilie Secret - 24 novembre 2020

Molecularly imprinted polymers (MIPs) have been widely used in nanomedicine the last few years.1,2 The imprinting process consists in the polymerization of a functional monomer in the presence of a molecule of interest (template) with a cross-linking agent. After the extraction of the molecule, the polymer matrix contains tailor-made binding sites, perfectly complementary to the extracted molecule. In contrast to biological antibodies, the synthesis of MIPs is fast and economic and they are physically and chemically stable.3 For example, MIP have been successfully employed by Cecchini et al.4 to target specific cells in zebra fish embryos and by Koide et al. to inhibit in vivo the action of the human endothelial growth factor.5 In 2018, Piletsky et al. developed an imprinted protein nanoparticle against Epidermal Growth Factor Receptor, the material can specifically recognize a native protein and passively deliver a drug payload to the corresponding cell target.6

Plasmonic nanomaterials such as gold or silver are the state of the art in the field of nanomedecine as theranostic agents.7 This is due to their fascinating optical properties resulting from the interaction of their surface plasmon resonance (SPR) with light. Upon irradiation with a suitable wavelength, plasmonic nanoparticles can absorb light and generate heat which can be used for example for thermal therapies and to kill cancer cells.

Combining inorganic plasmonic nanoparticles to MIP can open doors to a novel class of synthetic materials with applications in nanomedicine and more particularly for cancer therapy.

The goal of this M2 internship will be to synthesize new hybrid nanomaterials composed of a gold core and a MIP shell.

Specific techniques or methods The student will synthesize gold nanoparticles of different shapes and sizes suitable for applications in the field of nanomedecine (absorption in the near-infra-red (NIR)) and evaluate their photothermal properties in solution using lasers stimulation and an IR-camera. She/he will later modify the gold nanoparticles with a RAFT agent followed by the polymerization of the MIP. All materials will be characterized using DLS, TGA, TEM, UV, IR, XRD. The student could contribute to cell experiments tests too.

Internship period : February – June 2021. Dates can be adapted around this period. This internship will take place in PHENIX located on the Pierre et Marie Curie Campus of Sorbonne Université.

The internship will be adapted to the sanitary conditions and home working will be implemented if necessary.

Contact : nebewia.griffete@sorbonne-universite.fr (PHENIX) ali.abou_hassan@sorbonne-universite.fr (PHENIX)

References : 1. Haupt K, Medina Rangel P, Tse Sum Bui B, Chem. Rev, 17, 9554 (2020) 2. Shuxin X, Lisheng W, Zhen L, Angewandte (2020) https://doi.org/10.1002/anie.202005309 3. a) Nerantzaki M, Michel A, Briot E, Siaugue JM, Ménager C, Wilhelm C, Griffete N, Chem. Comm 56, 10255 (2020), b) Griffete N, Fresnais J, Espinosa A, Wilhelm C, Bée A, Ménager C Nanoscale 7, 18891 (2015) 4. Cecchini A, Raffa V, Canfarotta F, Signore G, Piletsky S, MacDonald MP, Cuschieri A, Nano Lett 17, 2307 (2017) 5. Koide H, et al. Nat. Chem. 9, 715 (2017) 6. Canfarotta F, et al. Nano Lett. 18, 4641 (2018) 7. https://pubs.rsc.org/en/content/art...