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Ali Abou-Hassan

Dr. Ali ABOU-HASSAN

Associate Professor

Sorbonne University, campus Pierre & Marie Curie, 4 place Jussieu, 75005, Paris, France

- Researcher ID:D-4411-2014
- E-mail : ali.abou_hassan@sorbonne-universite.fr
- Phone : +33 (0) 1 44 27 55 18
- Fax : +33 (0) 1 44 27 32 28

Personnal Website: https://aliabouhassan.wordpress.com/

Research areas

A) Synthesis of multi-scale and multifunctionnal nanomaterials combing different properties (magnetic and plasmonic ) using bulk and high-throughput microfluidic approaches. These synthesis are elaborated using bottom-up molecular or self-assembly approaches in bulk or using the physico-chemical advantages of microreactors. Many of these synthesis are devoted to applications in the field of nanomedecine particularly for cancer therapy and drug delivery. We are also interested by surface mofication of these nanomaterials.

B) Investigating the nucleation and growth mechanisms of inorganic materials such as the transformation of ferrihydrite to Goethite. We also study in a biomimetic approach the effect of confinement, flow and interfaces on the growth of kidney stones.

C) Elaboration of sel-oscillating systems and study of their self-organization in a biomimetic approach. Our aim is to learn some lessons to create multifunctionnal adaptable systems.

D) Biodegradation and biotransformation of multifunctionnal materials by cells using materials science approaches. What can we learn as chemists in pre-designing multifunctionnal materials for therapy? Can cells be used as factories to recreate and redesign the nanoarchitectures to new ones with new core and surface properties? Could they be used for therapy or personnalized nanomedecine?

Publications

- G. Laffite, C. Leroy, C. Bonhomme, L. Bonhomme-Coury, E. Letavernier, M. Daudon, V. Frochot, J. P. Haymann, S. Rouzière, I. T. Lucas, D. Bazin, F. Babonneau, A. Abou-Hassan Calcium oxalate precipitation by diffusion using laminar microfluidics: toward a biomimetic model of pathological microcalcifications, Lab Chip, 16, (2016) 1157-1160

- A. Espinosa, M. Bugnet, G. Radtke, S. Neveu, G. A. Botton, C. Wilhelm A. Abou-Hassan, Can magneto-plasmonic nanohybrids efficiently combine photothermia with magnetic hyperthermia?, Nanoscale, 7, (2015), 18872-18877

- K. Torbensen, F. Rossi, O-L. Pantani, S. Ristori, A. Abou-Hassan,Interaction of the Belousov-Zhabotinsky Reaction with Phospholipid Engineered Membranes, J. Phys. Chem. B, (2015) DOI:10.1021/acs.jpcb.5b04572

- K. Torbensen, A. Abou-Hassan, Easy-to-assemble and adjustable coaxial flow focusing microfluidic device for generating controllable water/oil/water double emulsions: toward templating giant liposomes with different properties, J. Flow. Chem., (2015), in Press

- N. Hassan, A. Stocco, A. Abou-Hassan, Droplet Liquid/Liquid Interfaces Generated in a Microfluidic Device for Assembling Janus Inorganic J. Phys. Chem. C. 19 (2015) 10758–10765

- F. Rossi, A. Zenati, S. Ristori, J-M. Noel, V. Cabuil, F. Kanoufi, A. Abou-Hassan, Activatory Coupling Among Oscillating Droplets Produced in Microfluidic Based Devices Int. J. unconv. Computing. 11 (2015) 21-34

- R. Tomasi, J.M. Noël, A. Zenati, F. Rossi, V. Cabuil, S. Ristori, F. Kanoufi, A. Abou-Hassan, Chemical communication between vesicles encapsulating an oscillatory chemical reaction, Chem. Sci. 5 (2014) 1854-1859

- N. Hassan, F. Oyarzún-Ampuero, P. Lara, S. Guerrero, V. Cabuil, A. Abou-Hassan, M. J. Kogan, A. Abou-Hassan,. Flow chemistry to control the synthesis of nano and microparticles for biomedical applications. Curr. Top. Chem. Med. 14 (2014) 676-689

- H. Dozol, G. Mériguet, B. Anican, V. Cabuil, H. Xu, D. Wang, A. Abou-Hassan, on the synthesis of gold nanoparticles using EDTA as a reducing agent, J. Phys. Chem. C.117 (2013) 20958–20966

- N. Hassan, V. Cabuil, A. Abou-Hassan, Microfluidic assisted assembly of fluorescent, plasmonic and magnetic nanostructures, ‘Angew. Chem. Intl. Ed. 49 (2013) (Cover of February).

- N. Hassan, V. Cabuil, A. Abou-Hassan, Assembling magneto-plasmonic microcapsules using a microfluidic device, Chem. Commun. 49 (2013) 412-414

- A. Abou-Hassan, S. Neveu, V. Dupuis, V. cabuil, Synthesis of Cobalt Ferrite Nanoparticles in Continuous-Flow Microreactors, RSC Adv. 2 (2012) 11263-11265.

- A. Seth, G. Bealle, E. Santanach-Carreras, A. Abou-Hassan, C. Ménager, Design of vesicles using capillary microfluidic devices: from magnetic to multifunctional vesicles, Adv. Mater. 24 (2012) 3544-35486.

- A. Abou-Hassan, Microreactors: a new tool for inorganic chemistry, L’Actualité Chimique 358 (2011) 13-18.

- A. Abou-Hassan, O. Sandre, V. Cabuil, Microfluidics in inorganic chemistry, Angew. Chem. Intl. Ed. 49 (2010) 6268-6286.8.

- A. Abou-Hassan, R. Bazzi, V. Cabuil, Multistep Continuous-Flow Microsynthesis of Magnetic and Fluorescent gamma-Fe2O3@SiO2 Core/Shell Nanoparticles, Angew. Chem. Intl. Ed. 48 (2009) 7180-7183.

- A. Abou-Hassan, O. Sandre, S. Neveu, V. Cabuil, Synthesis of Goethite by Separation of the Nucleation and Growth Processes of Ferrihydrite Nanoparticles Using Microfluidics, Angew. Chem. Int. Ed., 48 (2009) 2342-2345.

- A. Abou-Hassan, J.-F. Dufrêche, O. Sandre, G. Meriguet, O. Bernard, V. Cabuil, Fluorescence Confocal Laser Scanning Microscopy for pH Mapping in a Coaxial Flow Microreactor : Application in the Synthesis of Superparamagnetic Nanoparticles, J. Phys. Chem. C 113 (2009) 18097-18105.

- Abou-Hassan, O. Sandre, V. Cabuil, P. Tabeling, Synthesis of iron oxide nanoparticles in a microfluidic device: preliminary results in a coaxial flow millichannel. Chem. Comm. 15 (2008) 1783-1785.

Awards

- Best thesis in 2010 from the physical-chemistry division of the French Society of Chemistry